{"product_id":"thyroglobulin-human-thyroglobulin-human-100ug","title":"Thyroglobulin Human, Thyroglobulin Human, 100ug","description":"\u003ctable width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" border=\"0\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan style=\"font-weight: bold; font-family: Calibri; font-size: 10pt; color: rgb(0, 128, 0);\"\u003eCAT No.BT-PRO-443\u003c\/span\u003e\u003c\/td\u003e                                    \u003c\/tr\u003e                                   \u003ctr\u003e                                                \u003ctd\u003e    \u003cspan style=\"font-family: Arial; font-weight: 700; font-size: 12pt; color: rgb(128, 0, 0);\"\u003eThyroglobulin Human, Thyroglobulin Human, 100ug\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003chr\u003e\n\u003cp\u003e  Introduction\u003cbr\u003eThyroglobulin (TG) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. TG is a large globular dimeric glycoprotein with a total molecular weight of 660 kDa, which occupies a key precursor role in the biosynthesis of the thyroid hormones. Approximately 75% of the total protein content of the thyroid follicle consists of TG. The thyroid gland uses the Thyroglobulin in order to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is produced by the thyroid epithelial cells (thyrocytes) which form spherical follicles. Thyroglobulin is subsequently secreted and stored in the follicular lumen.\u003cbr\u003ePatients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against Thyroglobulin. Tg-specific antibodies help in the diagnosis of the above diseases, however they also may be present in apparently healthy euthyroid individuals. Blood Thyroglobulin levels can be used as a tumor marker for certain kinds of thyroid cancer, and the may also be elevated in cases of Graves' disease.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eCoating concentration\u003cbr\u003e0.7-1 ug\/ml (depending on the type of ELISA plate and coating buffer).\u003cbr\u003eSuitable for biotinylation and iodination.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eDescription\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eHuman Thyroglobulin is a glycosylated, polypeptide chain having a total molecular mass of 662 kDa (331 kDa per subunit).\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eHuman Thyroglobulin is supplied at a concentration of 0.82mg\/ml in 16mM HEPES buffer pH-7.6, 240mM sodium chloride, and 20% glycerol.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eImmunological functions\u003cbr\u003e1. Binds to IgG-type human auto-antibodies.\u003cbr\u003e2. Auto-antibodies to thyroglobulin recognize conformation-dependent epitopes.\u003cbr\u003e3. Standard ELISA test (checker-board analysis of positive\/negative sera panels, including 1st international reference serum NIBSC 65\/93).\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003ePurity\u003cbr\u003eGreater than 95% as determined by SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eSource\u003cbr\u003eNative, Isolated from human thyroid glands.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eStorage Conditions\u003cbr\u003eStore at 4¡ãC if entire vial will be used within 2-4 weeks. \u003cbr\u003eStore, frozen at -20¡ãCfor longer periods of time. \u003cbr\u003eAvoid multiple freeze-thaw cycles.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eSynonyms\u003cbr\u003eThyroglobulin, TGN, AITD3, TG.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eUsage\u003cbr\u003eTSZGENE's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":42034551914593,"sku":"BT-PRO-443","price":876.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0567\/9595\/5297\/files\/recom_protein_p_fe826856-31d8-4167-b42c-1567b49b98b8.jpg?v=1741097787","url":"https:\/\/biotangusa.com\/products\/thyroglobulin-human-thyroglobulin-human-100ug","provider":"Biotang USA","version":"1.0","type":"link"}