>Animal Surgical Service

SURGICAL SERVICES OVERVIEW

　

Our Company’s surgical team provides surgical modification animals and surgery-induced disease models for pre-clinic drug efficacy study and therapeutic strategy testing.
　

Our customers include institutes, leading research organizations and pharmaceutical biotechnology industries nationwide.
　

Biotang Inc. serves as a resource to provide expertise in animal disease model design, pre-instrumented animals, surgery-induced small animal models and on-site surgical technique support. Our surgical team also can develop specific techniques to meet your individual requirements and help accelerate your preclinical program.

　

Our surgical procedures are developed in-house and performed by scientists who have surgeon background with micro-surgical techniques.

　

We offer on-site surgical support that allow company’s surgeon to provide surgical services at your facility. The “Rent-A-Surgeon” program will sent one surgeon to your facility for an entire day to perform IACUC-approved surgical procedures as requested by you. Charges for Rent-A-Surgeon”are $2200 per day plus expenses.

　

Contact us to see completely pricing for our surgical services. Surgical procedures do not include the price of the animal, shipping and container charges.

　

If you have any questions, Contact us!

　

　

Rodent Surgical Modifications and Models

　

Non-vascular cannulation for short-term and long-term access: Rat Mouse
Intra-cerebroventricular cannulation √ √
Third ventricular cannulation √ √
Intrathecal cannulation √ √
Intra-spinal canal cannulation √ √
Gall-bladder cannulation √ √
Common bile duct cannulation √ √
Mesenteric lymphatic duct cannulation √ √
Thoracic lymphatic duct cannulation √ 　
Urinary Bladder cannulation √ √
Gastric cannulation √ √
Intestinal (duodenum, jejunum and ileum) cannulation √ √

　

Vascular cannulation for short-term and long-term access: Rat Mouse
Jugular vein cannulation √ √
Portal vein cannulation √ √
Femoral vein cannulation √ 　
Femoral artery cannulation √ 　
Carotid artery cannulation √ √

　

Injections and instillations: Rat Mouse
Intra-cerebroventricular injection √ √
Third ventricle injection √ √
Intra-spinal injection √ 　
Intra-thymus injection √ √
Intra-trachea or lungs injection and instillation √ √
Intra-nasal instillation √ √
Portal vein injection (open abdomen) √ √
Bone injection √ √

　

Organ resection procedures: Rat Mouse
Thymectomy √ √
Thyroidectomy √ √
Adrenalectomy √ √
Pancreatectomy (>70%) √ √
Hepatectomy (70%) √ √
Nephrectomy and Partial Nephrectomy (>70%) √ √
Small bowel resection (70%) √ √

　

Solid organ transplantation models: Rat Mouse
Skin transplantation √ √
Heterotopic cardiac transplantation √ √
Orthotopic liver transplantation √ √
Kidney transplantation √ √
Small bowel transplantation √ √
Aortic transplantation √ √
Kidney capsule grafting √ √

　

Cardiovascular disease models: Rat Mouse
Carotid artery ligation induces atherosclerosis √ √
Left coronary artery ligation induces myocardial infarction √ √
Cryoinjury-induced myocardial Infarction √ √
Myocardial ischemia and reperfusion model √ √
Isolated heart perfusion √ √
Abdominal aortic banding induces hypertension √ √
Thoracic aortic banding induces myocardial hypertrophy and hypertension √ √
Orthotopic aortic transplantation induces arteriosclerosis √ √
Femoral artery ligation induces ischemia model √ √

　

Thrombosis models: Rat Mouse
A-V shunt √ √
Stroke model √ √
Deep vein thrombosis model √ √

　

Digestive disease models: Rat Mouse
Esophagitis and Berratt’s Esophagus √ √
Short bowel syndrome √ √
Small bowel fistula √ √
Gastric fistula √ √

　

Pain disease models: Rat Mouse
L5/L6 spinal nerve ligation induces neuropathic pain model √ √
Partial sciatic nerve ligation induces neuropathic pain model √ √
Femur bone injection induces cancer pain model √ √
Calcaneus bone injection induces cancer pain model √ √
Tibia bone injection induces cancer pain model √ √

　

Orthotopic implantation induces primary cancer models: Rat Mouse
Lung cancer 　 √
Liver cancer 　 √
Kidney cancer 　 √
Stomach cancer 　 √
Small bowel cancer 　 √
Large bowel cancer (Colon, Racta) 　 √
Bone cancer (femur, Calcaneus, Tibia bone) 　 √

　

　

　

　

　

　

　

　

　

　

　

　

　

　

　

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