Important note: Products are intended for laboratory use and are not to be used for any other purpose, which include but are not limited to, unauthorized commercial uses, ex vivo or in vivo therapeutic uses. Not for Human or Animal Consumption.
Recombinant Human Bone Morphogenetic protein-7 (BMP-7), 100 ug
Bone morphogenetic protein 7 or BMP7 (also known as
osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the
BMP7 gene.
The protein encoded by this gene is a member of the TGF-β
superfamily. Like other members of the bone morphogenetic protein family of
proteins, it plays a key role in the transformation of mesenchymal cells into
bone and cartilage. It is inhibited by noggin and a similar protein, chordin,
which are expressed in the Spemann-Mangold Organizer. BMP7 may be involved in
bone homeostasis. It is expressed in the brain, kidneys and bladder.
BMP7 induces the phosphorylation of SMAD1 and SMAD5, which
in turn induce transcription of numerous osteogenic genes. It has been
demonstrated that BMP7 treatment is sufficient to induce all of the genetic
markers of osteoblast differentiation in many cell types
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Lead time 1-2 weeks. Shipped by FedEx.
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