Important note: Products are intended for laboratory use and are not to be used for any other purpose, which include but are not limited to, unauthorized commercial uses, ex vivo or in vivo therapeutic uses. Not for Human or Animal Consumption.
Recombinant Human Fibroblast Growth Factor-21, 100ug
Synonyms:
Fibroblast growth factor 21, FGF-21.
Fibroblast growth factor 21 is a protein that in humans is
encoded by the FGF21 gene. The protein encoded by this gene is a member of the
fibroblast growth factor (FGF) family. FGF family members possess broad
mitogenic and cell survival activities and are involved in a variety of
biological processes including embryonic development, cell growth,
morphogenesis, tissue repair, tumor growth and invasion.
FGF21 stimulates glucose uptake in adipocytes but not in other cell types. This
effect is additive to the activity of insulin. FGF21 treatment of adipocytes is
associated with phosphorylation of FRS2, a protein linking FGF receptors to the
Ras/MAP kinase pathway. FGF21 injection in ob/ob mice results in an increase in
Glut1 in adipose tissue. FGF21 also protects animals from diet-induced obesity
when overexpressed in transgenic mice and lowers blood glucose and triglyceride
levels when administered to diabetic rodents. Treatment of animals with FGF21
results in increased energy expenditure, fat utilization and lipid excretion.
Beta Klotho (KLB) functions as a cofactor essential for FGF21 activity.
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Lead time 1-2 weeks. Shipped by FedEx.
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